The observed deficiency of an important accumulation of PHN in Mind next the intraventricular administration of (+)-amphetamine along with the development of considerable quantities of PHN from (+)-POH in Mind tissue in vivo supports the view that the aromatic hydroxylation of amphetamine pursuing its systemic administration takes place predominantly within the periphery, and that POH is then transported throughout the blood-brain barrier, taken up by noradrenergic neurones in brain where (+)-POH is transformed from the storage vesicles by dopamine β-hydroxylase to PHN. ^
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